I assume the easiest would be to use a zipped notepad++ package and install in
two different places but if I’m right you are also aware of python script plugin and
another solution would be to do something like this

def change_styles():
    # editor.styleResetDefault()
    editor.styleSetBack(0, (30, 30, 30));  editor.styleSetFore(0,  (200, 200, 200));
    editor.styleSetBack(1, (30, 30, 30));  editor.styleSetFore(1,  (87, 166, 74));
    editor.styleSetBack(2, (30, 30, 30));  editor.styleSetFore(2,  (255, 128, 128));
    editor.styleSetBack(3, (30, 30, 30));  editor.styleSetFore(3,  (214, 157, 133));
    editor.styleSetBack(4, (30, 30, 30));  editor.styleSetFore(4,  (214, 157, 133));
    editor.styleSetBack(5, (30, 30, 30));  editor.styleSetFore(5,  (54, 125, 198));
    editor.styleSetBack(6, (30, 30, 30));  editor.styleSetFore(6,  (200, 200, 200));
    editor.styleSetBack(7, (30, 30, 30));  editor.styleSetFore(7,  (200, 200, 200));
    editor.styleSetBack(8, (30, 30, 30));  editor.styleSetFore(8,  (138, 138, 255));
    editor.styleSetBack(9, (30, 30, 30));  editor.styleSetFore(9,  (250, 205, 34));
    editor.styleSetBack(10,(30, 30, 30));  editor.styleSetFore(10, (255, 128, 0));
    editor.styleSetBack(11,(30, 30, 30));  editor.styleSetFore(11, (141, 166, 206));
    editor.styleSetBack(12,(30, 30, 30));  editor.styleSetFore(12, (87, 166, 74));
    editor.styleSetBack(13,(30, 30, 30));  editor.styleSetFore(13, (214, 157, 133));
    editor.styleSetBack(14,(30, 30, 30));  editor.styleSetFore(14, (0, 97, 194));
    editor.styleSetBack(15,(30, 30, 30));  editor.styleSetFore(15, (200, 200, 200));
    editor.styleSetBack(16,(30, 30, 30));  editor.styleSetFore(16, (200, 200, 200));
    editor.styleSetBack(17,(30, 30, 30));  editor.styleSetFore(17, (200, 200, 200));
    editor.styleSetBack(18,(30, 30, 30));  editor.styleSetFore(18, (200, 200, 200));
    editor.styleSetBack(19,(30, 30, 30));  editor.styleSetFore(19, (200, 200, 200));
    editor.styleSetBack(20,(30, 30, 30));  editor.styleSetFore(20, (200, 200, 200));
    editor.styleSetBack(21,(30, 30, 30));  editor.styleSetFore(21, (200, 200, 200));
    editor.styleSetBack(22,(30, 30, 30));  editor.styleSetFore(22, (200, 200, 200));
    editor.styleSetBack(23,(30, 30, 30));  editor.styleSetFore(23, (200, 200, 200));
    editor.styleSetBack(24,(30, 30, 30));  editor.styleSetFore(24, (200, 200, 200));
    editor.styleSetBack(25,(30, 30, 30));  editor.styleSetFore(25, (200, 200, 200));
    editor.styleSetBack(26,(30, 30, 30));  editor.styleSetFore(26, (200, 200, 200));
    editor.styleSetBack(27,(30, 30, 30));  editor.styleSetFore(27, (200, 200, 200));
    editor.styleSetBack(28,(30, 30, 30));  editor.styleSetFore(28, (200, 200, 200));
    editor.styleSetBack(29,(30, 30, 30));  editor.styleSetFore(29, (200, 200, 200));
    editor.styleSetBack(30,(30, 30, 30));  editor.styleSetFore(30, (200, 200, 200));
    editor.styleSetBack(31,(30, 30, 30));  editor.styleSetFore(31, (200, 200, 200));
    editor.styleSetBack(32,(30, 30, 30));  editor.styleSetFore(32, (200, 200, 200));
    editor.styleSetBack(33,(30, 30, 30));  editor.styleSetFore(33, (43, 145, 175));
    editor.styleSetBack(34,(38, 79, 120)); editor.styleSetFore(34, (220, 220, 220));
    editor.styleSetBack(35,(30, 30, 30));  editor.styleSetFore(35, (147, 0, 0));
    editor.styleSetBack(36,(30, 30, 30));  editor.styleSetFore(36, (200, 200, 200));
    editor.styleSetBack(37,(30, 30, 30));  editor.styleSetFore(37, (136, 138, 133));
    editor.styleSetBack(38,(0, 0, 0));     editor.styleSetFore(38, (128, 128, 128));
    
    editor.setCaretFore((128, 128, 128))
    editor.setCaretLineBack((0, 0, 0))
    
    for i in range(15):
        editor.styleSetFont(i, 'Courier New')
        editor.styleSetSize(i,12)
    
    editor.setFoldMarginColour(True, (30, 30, 30))
    editor.setFoldMarginHiColour(True, (30, 30, 30))

def callback_BUFFERACTIVATED(args):
    if editor.getLexer() in [1,2]:
        change_styles()
    else:
        editor.setFoldMarginColour(False, (30, 30, 30))
        editor.setFoldMarginHiColour(False, (30, 30, 30))
        

notepad.clearCallbacks([NOTIFICATION.BUFFERACTIVATED])
notepad.callback(callback_BUFFERACTIVATED, [NOTIFICATION.BUFFERACTIVATED])

Put this into the user startup.py.
Basically, every time you switch/open a document it checks if it is either a normal text
or python document and in such a case changes the styles.
The meaning of the styles can be seen in stylers.xml but be aware that not
every style id from global styles can be set but needs to be callled with a different
function like setFoldMarginColour etc…

Cheers
Claudia