I’ve not much idea myself about AppDomains, but I am swatting up. I’m also learning about Managed Extensibility Framework (MEF) and Managed AddIn Framework (MAF) to see if they can help.

@Makwana-Prahlad
Thanks for the example - easier for me than theory sometimes!

Follow this information,To C# plugins share AppDomain?

1.Check if the assembly is already loaded
2.If its not loaded, read the assembly into a byte array. This will prevent locking the file.
3.Supply the byte array as an arguement to Assembly.Load

Assembly assembly = null;

foreach(Assembly loadedAssembly in AppDomain.CurrentDomain.GetAssemblies())
    if (loadedAssembly.FullName == "foobar, Version=1.0.0.0, Culture=neutral, PublicKeyToken=null")
        assembly = loadedAssembly;

if(assembly == null)
{
    byte[] studybin = System.IO.File.ReadAllBytes(@"C:\pathToAssembly\foobar.dll");
    assembly = Assembly.Load(studybin);                
}

Note :
If you are trying to find a specific assembly in a directory, you can run ‘System.Reflection.AssemblyName.GetAssemblyName(path);’ to see if the FullName matches what you are looking for. ‘GetAssemblyName(path)’ does NOT inject the assembly into your current AppDomain.

I hope this information will be usefull.
Thank you.

what about this, sounds like you can isolate the domains. Note, I have no idea what I’m talking about.