scaling / math. operations with colums

Hello, is there a option to do math operations with columns? A transformation of the units could be neccessary, scaling by 1E03. Any help is welcome. 
Natively, no. Notepad++ is a text editor, not a spreadsheet. Open your text file in Excel or OpenOffice/LibreOffice Calc or some other spreadsheet application, do the math, and save it again.
If you are willing to use a scripting plugin for Notepad++, it can be done, with more work. The Mathematical Replacement FAQ has all the details you need if you are willing to put in the effort yourself.