This is the point when you need to start reading and understanding where to find regex documentation, which I linked earlier.
This is not a professional regex-writing forum. We are users of Notepad++, who want to help others learn more about NPP (and learn more ourselves, in the process). Since Notepad++ makes use of regular expressions, we will often provide help with regex questions.
However, after this many rounds, you really need to start applying what you’re learning. Because you are learning, right? We’re not just doing your job for you. Because if we were, we’d be charging you consulting rates.
To reluctantly answer your question, “Suppose the symbol is not : its a ?”. The obvious choice would be to try replacing the : from the regex with a ?. Did you try that? What happened? If you did try it, it wouldn’t have matched, so you could have said “when I tried to replace the : with a ? in the regex, it didn’t match/highlight the question mark when I hit FIND, or replace the ? when I hit REPLACE… Why not?” At that point, you would have shown a willingness to learn how to do it, to generalize from what you’ve been shown, and to ask questions about what you tried, rather than hoping we’d do all the work for you. (Such a lost opportunity. :-( )
After you asked that question, one of us could have replied, "if you follow the link to where to find regex docs, the first link there is the NppWiki:Regular Expressions page; you can search that page for ?, and learn that in regular expressions, ? means to match 0 or 1of the last character – the last “character”, in that case, actually being the match in parenthesis just before it. If you want to match the literal of a special character in a regex, you have to escape it by putting a \ in front of it… so to match a literal question mark, you would use the sequence of \? in your regex.
So, if I take @guy038’s (?-s)((?:.*(\R)){2}.*football):?, which matches to a colon, I would change it to (?-s)((?:.*(\R)){2}.*football)\?? to match a question mark instead.
If you’re going to be doing more regular expressions, spend some time in the list of regex documentation. It will help you.