@triplel55569
if @Alan-Kilborn is correct, then you will have to edit your shortcuts.xml file:
on installed versions of notepad++ (not portable versions) the correct location of your shortcuts.xml is: %AppData%\Notepad++\shortcuts.xml
(this alias will lead you to C:\Users\YourUserName\AppData\Roaming\Notepad++\shortcuts.xml)
choose file > open at the notepad++ menu.
paste %AppData%\Notepad++\shortcuts.xml into the file name input field and hit open to open your shortcuts xml.
paste/insert one or more of the following lines in the black area, anywhere into your <UserDefinedCommands> area:
<Command name="Launch in Firefox" Ctrl="yes" Alt="yes" Shift="yes" Key="88">firefox "$(FULL_CURRENT_PATH)"</Command>
<Command name="Launch in IE" Ctrl="yes" Alt="yes" Shift="yes" Key="73">iexplore "$(FULL_CURRENT_PATH)"</Command>
<Command name="Launch in Chrome" Ctrl="yes" Alt="yes" Shift="yes" Key="82">chrome "$(FULL_CURRENT_PATH)"</Command>
save shortcuts.xml and restart notepad++
now your run menu and your shortcuts.xml should look similar or equal to this screenshot:
Imgur
please report back if it works for you.