Is this possible?
Nope.
Notepad++ is a text editor. It is for looking at and editing the source code, it is not a rendering engine.
That said, there are some text formats, like Markdown, which can markup text, and if you have a rendering engine, that text will be rendered differently. You can use the Notepad++ Plugins > Plugins Admin to install the MarkdownViewer++ plugin, which embeds a Markdown rendering engine in Notepad++; using that plugin, you can edit the Markdown source code in one pane of Notepad++, and have it rendered in the MarkdownViewer++ pane of Notepad++. In such a circumstance, using the Markdown syntax [Debian](https://debian.org) would render in the MarkdownViewer++ pane as Debian, while still being clickable in the viewer pane.